Abstract

Pharmacological Aspects and Clinical Implications of Tea (Camellia Sinensis) Bioactive Compounds Against Prostate Cancer

Mingxi Li¹, Muhammad Farrukh Nisar^2,3, Yudi Gan¹and Chunpeng Wan^1,2*

¹Research Center of Tea and Tea Culture, College of Agronomy, Jiangxi Agricultural University, Nanchang, China.

²Jiangxi Provincial Key Laboratory for Postharvest Storage and Preservation of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, China.

³Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur, Pakistan.

Corresponding Author E-mail:chunpengwan@jxau.edu.cn

Abstract:

Prostate cancer is one of the most common malignancies and ranks with the most frequent causes of cancer fatalities in men. The chemoprevention approaches of prostate cancer (PC) are on the continuous rise due to desire to lessen prevalence and aggressiveness of the disease. Phytochemicals of tea especially from Camellia sinensis have emerged as promising candidates due to their antioxidant, anti-inflammatory and possible anti-cancer characteristics. Key compounds such as catechins (notably EGCG), flavonoids (quercetin, kaempferol), alkaloids (caffeine, theobromine), amino acids (theanine), as well as vitamins, minerals, and volatile oils, collectively contribute to the biological activities. These bioactive compounds (BACs) affect all the pathways linked to PC such as oxidative stress, inflammation, and signaling cascade routes. This article synthesizes current research findings on the mechanisms by which tea-derived BACs may exert chemopreventive effects against PC. Future research directions and clinical advancements are outlined, providing a framework for translating these findings into practical applications for PC prevention and treatment.

Keywords:

Bioactive compounds; Chemoprevention; Camellia sinensis; EGCG; Prostate cancer

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