Low 25 Hydroxyvitamin D and High Leptin Level as Risk Factors of Metabolic Syndrome in Obese Women

Luh Putu Ratna Sundari^1*, Susy Purnawati¹, I Ketut Tunas² and I Wayan Weta³

¹Department of Physiology, Faculty of Medicine, Udayana University, Bali, Indonesia.

²Department of Health Information Management, Faculty of Health Sciences, Bali International University, Bali. Indonesia.

³Department of Clinical Nutrition Science, Faculty of Medicine, Udayana University, Bali.

Corresponding Author Email: luhputu_ratnafk@unud.ac.id

Obesity is associated with low vitamin D levels and high leptin levels. The aim of this study is to see if low vitamin D levels and high leptin levels are risk factors for metabolic syndrome in obese women. This study use case control study to observe the difference of leptin and vitamin D plasma level as risk factor of metabolic syndrome on obesity women. There are 34 obese women as the sample of study. Subject is divided randomly into 2 groups, where each of groups consists of 17 obese with syndrome metabolic case and 17 obese women as control. Each group was tested for its vitamin D and leptin level. The relationship between vitamin D and leptin levels and metabolic syndrome was then investigated using the Chi Square test, and logistic regression was taken to discover odds ratio (OR). The result is p=0.031, and OR=5.25; CI 95% which means the group with low vitamin D has risk factors for metabolic syndrome by 5 times than the control group high vitamin D. It was obtained p=0.001, and OR= 256; CI 95% means that the case group with high leptin is the risk factors of the occurred metabolic syndrome by 256 times than low level of leptin in control group. It is concluded that in this study there is a link between low vitamin D levels and high leptin levels as risk factors of metabolic syndrome found in obesity.

Leptin; Metabolic Syndrome; Obesity; Vitamin D; Women

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