Altered Lipid Responses to Dietary Interventions in Obesity

Meena L Godhia and Nagma Naik^*

Department of Food and Nutrition, SVT College of Home Science, SNDT Women’s University, SNDT Vidyavihar, Juhu ,Mumbai- 400 049.

Dietary interventions target at reducing dietary saturated fatty acid and cholesterol to decrease the CVD risk. Currently, studies show that presence of excess adipose tissue seems to alter lipid and lipoprotein response to plasma cholesterol lowering diet. Diets low in SFA and dietary cholesterol are less efective in improving lipid profiles of obese individuals as compared to lean individuals. There are multiple mechanism which leads to altered response like decrease in LDL receptor activity, increased inflammation, abnormal function of enzymes involved in lipid metabolism and insulin resistance. Thus, normalizing adipose tissue mass is an important goal for maximizing the diet response to a plasma cholesterol–lowering diet.

Metabolic Syndrome; Inflammatory Markers; Pro Inflammatory Pathway; Dietary Saturated Fatty Acid and Cholesterol

[ HTML Full Text]