Dietary Fresh and Boiled Mangkokan Leaves (Nothopanax Scutellarius) Normalized Body Weight, Serum Lipid Profile and Malondialdehyde in Metabolic Syndrome Rats

Devi Elvina Rachma¹, Retno Murwani^1,2,3*and Achmad Zulfa Juniarto^4,1

¹Department of Nutrition, Master Programme in Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia.

²Department of Animal Sciences, Laboratory of Physiology and Biochemistry, Faculty of Animal and Agricultural Sciences, Universitas Diponegoro, Semarang, Indonesia.

³Natural Product Laboratory, Integrated laboratory for Research and Services (Laboratorium Terpadu), Universitas Diponegoro, Semarang, Indonesia.

⁴Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia.

Corresponding Author Email: rmurwani.undip@gmail.com

The antioxidant activity of Nothopanax scutellarius (Burm. f.) Merr, an edible plant, can prevent oxidative stress in metabolic syndrome (MetS). Thus, our research aimed to study the effect of dietary inclusion of fresh or boiled N. scutellarius on body weight and biochemical markers of Wistar rats with MetS. Twenty-four male Wistar rats were divided randomly into four groups, i.e., normal control group, high-fat-high-fructose diet (HFFD) group, fresh N. scutellarius (FNs) group, and boiled N. scutellarius (BNs) group. The normal control group was fed only a standard diet during the entire experiment. High-fat and high-fructose (HFHFr) diet accompanied with 20% fructose in drinking water to induce MetS was given to the HFFD, FNs, and BNs groups for 29 days. This was followed by a 29-day intervention diet in which standard normal diet, fresh N. scutellarius-containing standard diet, and boiled N. scutellarius-containing standard diet were given to the HFFD, FNs, and BNs groups, respectively. HFHFr diet significantly (p less than 0.05) raised fasting blood glucose (FBG), serum triglyceride, total cholesterol, LDL-cholesterol, and malondialdehyde (MDA), and significantly (p less than 0.05) reduced HDL-cholesterol. After 29 days on the intervention diet, serum triglycerides, total cholesterol, and LDL-cholesterol levels were found to decrease, and HDL-cholesterol levels were found to increase significantly (p less than 0.05). Thus, it can be concluded that dietary intake of N. scutellarius for 29 days can improve MetS components, i.e., FBG, serum lipid profile, and MDA, similar to those seen in rats on a normal control diet.

Dyslipidemia; My Plate; Phytonutrien; Piringku; Vegetables

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