Effect of Annona Muricata L. on Metabolic Parameters in Diabetes Mellitus: A Systematic Review

Iqdam Abdulmaged Alwan¹, Vuanghao Lim¹, Nozlena Abd Samad¹, Tri Widyawati², Nor Adlin Yusoff^1*

¹Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang 13200, Malaysia
²Pharmacology and Therapeutic Department, Faculty of Medicine, Universitas Sumatera Utara, 20155, Medan, Indonesia

Corresponding Author Email: noradlinyusoff@usm.my

In recent decades, numerous scientific investigations have been conducted to study the antidiabetic effects of Annona muricata L. However, no comprehensive evidence-based systematic review regarding this topic is available. Hence, this study was conducted to systematically evaluate the studies of the efficacy of A. muricata in diabetes management. Six online databases used to search for the related articles. The search terms used were A. muricata/ soursop in combination with diabetes, glucose, and insulin. Seventeen studies were identified that fit the inclusion criteria (1 clinical, 10 in vivo, 4 in vitro, 1 in vivo/ in vitro and 1 in silico). A clinical study showed the positive adjuvant effect of A. muricata to glibenclamide in type 2 diabetes patients. In vivo studies reported beneficial effects of A. muricata in murine models to include decreasing fasting blood glucose level, attenuating diabetes-associated weight loss, increasing serum insulin, improving the lipid profile, normalizing the activity of antioxidant enzymes, and exerting pancreas-protective and hepatoprotective effects. In vitro studies of A. muricata demonstrated its potential for reducing post-prandial glucose level by inhibiting pancreatic α-amylase, lipase, and α-glucosidase and lowering oxidative stress by inhibiting glycation and lipid peroxidation. Additionally, the in-silico study suggested a positive effect of A. muricata in enhancing insulin sensitivity. A. muricata showed a promising effect on the metabolic parameters in diabetes mellitus. Considering that A. muricata is widely consumed worldwide, further exploration of its therapeutic potential is worthwhile.

Annona Muricate; Diabetes Mellitus; Medicinal Plant; Nutritional Food; Soursop

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